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The physical mechanisms behind the fragmentation of high-mass dense clumps into compact star-forming cores and the properties of these cores are fundamental topics that are heavily investigated in current astrophysical research. The ALMAGAL survey provides the opportunity to study this process at an unprecedented level of detail and statistical significance, featuring high-angular resolution 1.38 mm ALMA observations of 1013 massive dense clumps at various Galactic locations. These clumps cover a wide range of distances (~2–8 kpc), masses (~10²–10⁴M_⊙), surface densities (0.1–10 g cm⁻²), and evolutionary stages (luminosity over mass ratio indicator of ~0.05 <L/M <450L_⊙/M_⊙). Here, we present the catalog of compact sources obtained with theCuTExalgorithm from continuum images of the full ALMAGAL clump sample combining ACA-7 m and 12 m ALMA arrays, reaching a uniform high median spatial resolution of ~1400 au (down to ~800 au). We characterize and discuss the revealed fragmentation properties and the photometric and estimated physical parameters of the core population. The ALMAGAL compact source catalog includes 6348 cores detected in 844 clumps (83% of the total), with a number of cores per clump between 1 and 49 (median of 5). The estimated core diameters are mostly within ~800–3000 au (median of 1700 au). We assigned core temperatures based on theL/Mof the hosting clump, and obtained core masses from 0.002 to 345M_⊙(complete above 0.23 M_⊙), exhibiting a good correlation with the core radii (M ∝ R^2.6). We evaluated the variation in the core mass function (CMF) with evolution as traced by the clumpL/M, finding a clear, robust shift and change in slope among CMFs within subsamples at different stages. This finding suggests that the CMF shape is not constant throughout the star formation process, but rather it builds (and flattens) with evolution, with higher core masses reached at later stages. We found that all cores within a clump grow in mass on average with evolution, while a population of possibly newly formed lower-mass cores is present throughout. The number of cores increases with the core masses, at least until the most massive core reaches ~10M_⊙. More generally, our results favor a clump-fed scenario for high-mass star formation, in which cores form as low-mass seeds, and then gain mass while further fragmentation occurs in the clump. 

Context. A large fraction of stars form in clusters containing high-mass stars, which subsequently influences the local and galaxy-wide environment. Aims. Fundamental questions about the physics responsible for fragmenting molecular parsec-scale clumps into cores of a few thousand astronomical units (au) are still open, that only a statistically significant investigation with ALMA is able to address; for instance: the identification of the dominant agents that determine the core demographics, mass, and spatial distribution as a function of the physical properties of the hosting clumps, their evolutionary stage and the different Galactic environments in which they reside. The extent to which fragmentation is driven by clumps dynamics or mass transport in filaments also remains elusive. Methods. With the ALMAGAL project, we observed the 1.38 mm continuum and lines toward more than 1000 dense clumps in our Galaxy, withM≥ 500 M_⊙, Σ ≥ 0.1 g cm⁻²andd≤ 7.5 kiloparsec (kpc). Two different combinations of ALMA Compact Array (ACA) and 12-m array setups were used to deliver a minimum resolution of ∼1000 au over the entire sample distance range. The sample covers all evolutionary stages from infrared dark clouds (IRDCs) to H IIregions from the tip of the Galactic bar to the outskirts of the Galaxy. With a continuum sensitivity of 0.1 mJy, ALMAGAL enables a complete study of the clump-to-core fragmentation process down toM∼ 0.3 M_⊙across the Galaxy. The spectral setup includes several molecular lines to trace the multiscale physics and dynamics of gas, notably CH₃CN, H₂CO, SiO, CH₃OH, DCN, HC₃N, and SO, among others. Results. We present an initial overview of the observations and the early science product and results produced in the ALMAGAL Consortium, with a first characterization of the morphological properties of the continuum emission detected above 5σin our fields. We used “perimeter-versus-area” and convex hull-versus-area metrics to classify the different morphologies. We find that more extended and morphologically complex (significantly departing from circular or generally convex) shapes are found toward clumps that are relatively more evolved and have higher surface densities. Conclusions. ALMAGAL is poised to serve as a game-changer for a number of specific issues in star formation: clump-to-core fragmentation processes, demographics of cores, core and clump gas chemistry and dynamics, infall and outflow dynamics, and disk detections. Many of these issues will be covered in the first generation of papers that closely follow on the present publication. 

Granular materials produce audio-frequency mechanical vibrations in air and structures when manipulated. These vibrations correlate with both the nature of the events and the intrinsic properties of the materials producing them. We therefore propose learning to use audio-frequency vibrations from contact events to estimate the flow and amount of granular materials during scooping and pouring tasks. We evaluated multiple deep and shallow learning frameworks on a dataset of 13,750 shaking and pouring samples across five different granular materials. Our results indicate that audio is an informative sensor modality for accurately estimating flow and amounts, with a mean RMSE of 2.8g across the five materials for pouring. We also demonstrate how the learned networks can be used to pour a desired amount of material. 

X-ray free electron laser (XFEL) sources coupled to high-power laser systems offer an avenue to study the structural dynamics of materials at extreme pressures and temperatures. The recent commissioning of the DiPOLE 100-X laser on the high energy density (HED) instrument at the European XFEL represents the state-of-the-art in combining x-ray diffraction with laser compression, allowing for compressed materials to be probed in unprecedented detail. Here, we report quantitative structural measurements of molten Sn compressed to 85(5) GPa and ∼3500 K. The capabilities of the HED instrument enable liquid density measurements with an uncertainty of ∼1% at conditions which are extremely challenging to reach via static compression methods. We discuss best practices for conducting liquid diffraction dynamic compression experiments and the necessary intensity corrections which allow for accurate quantitative analysis. We also provide a polyimide ablation pressure vs input laser energy for the DiPOLE 100-X drive laser which will serve future users of the HED instrument. 

Abstract Aging, often considered a result of random cellular damage, can be accurately estimated using DNA methylation profiles, the foundation of pan-tissue epigenetic clocks. Here, we demonstrate the development of universal pan-mammalian clocks, using 11,754 methylation arrays from our Mammalian Methylation Consortium, which encompass 59 tissue types across 185 mammalian species. These predictive models estimate mammalian tissue age with high accuracy (r > 0.96). Age deviations correlate with human mortality risk, mouse somatotropic axis mutations and caloric restriction. We identified specific cytosines with methylation levels that change with age across numerous species. These sites, highly enriched in polycomb repressive complex 2-binding locations, are near genes implicated in mammalian development, cancer, obesity and longevity. Our findings offer new evidence suggesting that aging is evolutionarily conserved and intertwined with developmental processes across all mammals.